Tamiflu-Renal Impairment

 

TAMIFLU Partial Insert Below from the FDA

Data are available on plasma concentrations of oseltamivir carboxylate following various dosing schedules in
patients with renal impairment [see Clinical Pharmacology (12.3)].
Treatment of Influenza
Dose adjustment is recommended for adult patients with creatinine clearance between 10 and 30 mL/min
receiving TAMIFLU for the treatment of influenza. In these patients it is recommended that the dose be reduced
to 75 mg of TAMIFLU once daily for 5 days. No recommended dosing regimens are available for patients with
end-stage renal disease undergoing routine hemodialysis or continuous peritoneal dialysis treatment.
Prophylaxis of Influenza
For the prophylaxis of influenza, dose adjustment is recommended for adult patients with creatinine clearance
between 10 and 30 mL/min receiving TAMIFLU. In these patients it is recommended that the dose be reduced
to 75 mg of TAMIFLU every other day or 30 mg TAMIFLU every day. No recommended dosing regimens are
available for patients undergoing routine hemodialysis and continuous peritoneal dialysis treatment with endstage

 

FULL INSERT FOR TAMIFLU
renal disease.

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